دکتر سیده ملیحه صفوی

مرتبه علمی:

دانشیار

سمت:

رئیس پژوهشکده

گروه پژوهشی:

گروه زيست انرژی و فرآيندهای تبديلی

ایمیل:

m.safavi@irost.ir

msafavi@ut.ac.ir

safavi_maliheh@yahoo.com

تلفن:

021-57416804

021-57416338

فاکس:

021-57416803

تب‌های عمودی

تحصیلات

تحصیلات:

Postdoctoral researcher, Pharmacology Faculty, Tehran University of Medical Sciences, Tehran, Iran (2013 March- 2013 November)
PhD in Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran(2008 October-2013 March)
Msc in Clinical Biochemistry, Tabriz University of Medical Sciences, Faculty of Medicine (2001-2003).
Bsc in Biology. Guilan University (1998-2001).

زمینه های علاقه

زمینه های علاقه:

1. طراحی و مهندسی نانوذرات برای حمل ژن ها جهت ناک داون ژنهای مرتبط با سرطان
2. ساخت نانوذرات آهسته رهش حامل داروهای ضد سرطان
3. شناسایی و استخراج متابولیت های با فعالیت های زیستی مختلف مانند ضد سرطان، ضد آلزایمر و فتوپروتکتیو از منابع طبیعی
4. طراحی و تعیین مکانیسم ترکیبات شیمیایی هدفمند برای درمان سرطان مورد نیاز صنایع دارویی
5. استخراج و تولید نیمه صنعتی هپارین

انتشارات

کتاب‌ها

کتاب ها:

Essentials of Pharmatoxicology in Drug Research

Pharmacokinetics and Toxicokinetic Considerations

Biopharmaceutics and Pharmacokinetics Considerations. Chapter 9 - Pharmacokinetics modeling in drug delivery

The Future of Pharmaceutical Product Development and Research Chapter 11 - Recent advances in regenerative medicine.

مقاله در کنفرانس

مقاله در کنفرانس:

Biomanufacturing of Natural Products using Microalgae

Comparative analysis of exopolysaccharide production by two native Iranian strains of lactic acid bacteria derived from dairy products

Enhancing the production of bioplastic poly-3-hydroxybutyrate-co-3-hydroxyvalerate from Bacillus cereus N6 strain

Evaluation of antioxidant activity of different concentrations of exopolysaccharides isolated from two strains of lactic acid bacteria

Machine Learning-Assisted Insights into Silver Nanoparticle Synthesis: The Role of Natural Reduction Sources

Antioxidant capacity of C-phycocyanin obtained from Arthrospira platensis by different method extraction and purification

Clone of Microalgae exopolysaccharides: Postbiotic with anti-adhesive properties

Extraction of antioxidant bioactive compounds from Iranian native Chlorella sp. microalgae

Microalgae Polysaccharide a Promising Natural Food Supplement Source

Optimization of Extraction of Phytosterols from the Green Hull of Khanjari Damghan Pistachio

Evaluation of antibacterial activity of three different extracts of Ganoderma Applanatum and G. Adspersum collected from North Iran

The study of antibacterial activity of laccate Ganoderma collected from hyrcanian forests.

Anticancer properties of microalgae s extract

Antioxidant and ACEinhibitory of two synthetic peptides identified from Saccharomyces cerevisiae protein hydrolysis

In silico gastrointestinal and stability study of a new symthetic antioxidant and ACE inhivbitory peptide

Protection against H2O2 induced cytotoxicity in PC12 cells by…

Anticancer activity of hydroalcoholic leaves extract of Ailanthus altissimia on MCF-7 breast cancer cell line

Isolation and screening of pigment producing Actinobacteria from soil.

Apoptosis induction of 2H-chromene derivatives on human breast cancer cells.

Extraction of curcuminoid from turmeric by ethanol using boiling mechanism.

The apoptosis inducing effects of new flavanone derivatives in human prostate cancer cell lines

Anticancer activity of piperazin-1-ylnaphthyridin-3- carboxylic acid derivatives against three breast cancer cell lines

Antiproliferative effects of some new methylenedioxychroman-4-one derivatives.

Cytotoxic activity of thiazole thiones on human breast cancer cell lines.

Generation of Reactive Oxygen Species by a series of chromen derivatives.

Novel chalcone and flavanone analogues as apoptosis inducer.

Novel Pyrazolo [3, 4-d] Pyrimidine Derivatives as Breast Anticancer Agents

Novel thiazole thione derivatives as apoptosis inducer

The anti cancer activity of novel chalcone and flavanone analogues.

Anticancer activity of some Benzylidene cyclohexanone derivatives.

In vitro cytotoxicity study of some 6- chloro-2H-chromene derivatives on five human cancer cell lines

Anti-cancer activities of a series of novel heterocyclic cyclohexanone curcumin derivatives

Evaluation of cytotoxic effects and matrix metalloprotease inhibition of some synthetic flavonoids

Antibacterial activity of plant extracts against H.pylori. Helicobacter

Synthesis and evaluation of superoxide dismutase activity of 2- hydroxyacetophenone semicarbazones and thiosemicarbazonescomplexes.

Translocation down syndrome; report of four de novo cases from Iran.

An unusual finding in couples with 6 recurrent abortions.

Relation of microalbuminuria with hypertension and diabetes in patients with cardiovascular disease

Production of polyclonal antibody in rabbit against rat immunoglobulin.

Relationship between microalbuminuria and extension of coronary atherosclerotic lesions

مقاله های مجله

مقاله های مجله:

Applications of Metal−Organic Frameworks (MOFs) in Drug Delivery, Biosensing, and Therapy: A Comprehensive Review

Essential oil of hymenocrater longiflorus benth. as a pro-apoptotic agent in human breast cancer cells

Extraction of Phytosterols from the Green Hull of Pistacia vera L. var Damghan and Optimization of Extraction Methods

Inhibition of EGFR1 in Triple Negative Breast Cancer Cells Using siRNA Loaded with Fe3O4 Magnetic Nanoparticles

Investigating the efect of cerium oxide nanoparticle on beta amyloid induced memory loss

MIL-101 magnetic nanocarrier for solid-phase delivery of doxorubicin to breast and lung cancer cells

Novel quinazolines bearing 1, 3, 4-thiadiazole-aryl urea derivative as anticancer agents: design, synthesis, molecular docking, DFT and bioactivity evaluations

Protective activity of Chlorella vulgaris microalgae extract on the in vitro cultured oocytes

Synthesis, biological evaluation, and in silico study of novel coumarin-quinazoline analogs as potential Anti-Angiogenesis agents

Visible-light-activated Fe2O3–TiO2 nanoparticles enhance biofouling resistance of polyethersulfone ultrafiltration membranes against marine algae Chlorella vulgaris

Exosomes as mediators of chemical-induced toxicity

A Mesoporous Magnetic Fe3O4/BioMOF-13 with a Core/Shell Nanostructure for Targeted Delivery of Doxorubicin to Breast Cancer Cells

Clone of Coupling Non-Linear Regression Analysis with a Predictive Model Using Spectrophotometric Data to Estimate Microalgae Concentration

Dunaliella salina HTBS

Enhanced production of bioactive compounds from marine microalgae Tetraselmis tetrathele under salinity and light stresses: A two-stage cultivation strategy

Fungal decolorization of toxic Triphenylmethane dye by newly isolated Ganoderma fungi: Growth, enzyme activity, kinetics.

Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review

Improving biomass and carbohydrate production of microalgae in the rotating cultivation system on natural carriers

Phytochemical Screening and In Vitro Antioxidant Activity of Extracts of Ipomoea purpurea Leaves from Iran

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

Coupling Non-Linear Regression Analysis with Predictive Model by Spectrophotometric Data for Estimation Microalgae Concentration

A Novel Salt-bridge Electroflocculation Technology for Harvesting Microalgae.

Butylated hydroxyl-toluene, 2,4-Di-tert-butylphenol, and phytol of Chlorella sp. protect the PC12 cell line against H2O2-induced neurotoxicity.

Characterization, antioxidant and anticoagulant properties of exopolysaccharide from marine microalgae.

Combination of bicarbonate and low temperature stress induces the biosynthesis of both arachidonic and docosahexaenoic acids in alkaliphilic microalgae Dunaliella salina HTBS.

Evaluation of anticancer and epidermal growth factor receptor inhibition activity by benzochromeno pyrimidin derivatives in three human cancer cell lines.

In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation

New insights into the inhibitory roles and mechanisms of D-amino acids in bacterial biofilms in medicine, industry, and agriculture.

Overcoming the non-kinetic activity of EGFR1 using multi-functionalized mesoporous silica nanocarrier for in vitro delivery of siRNA.

Sour-cherry seed polyphenol contents, antioxidant activity and nutritional components as a potential bioactive source

Synthesis and biological activity profile of novel triazole/quinoline hybrids.

Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease.

Untargeted metabolomics analysis of crocus cancellatus subsp. damascenus (Herb.) B. mathew stigmas and their anticarcinogenic effect on breast cancer cells.

Anticancer activity of ipomoea purpurea leaves extracts in monolayer and three-dimensional cell culture

Antioxidant and cytoprotective effects of synthetic peptides identified from Kluyveromyces marxianus protein hydrolysate: insight into the molecular mechanism

Design, synthesis and apoptosis inducing activity of nonsteroidal flavone-methanesulfonate derivatives on MCF-7 cell line as potential sulfatase inhibitor.

Effects of extracted polysaccharides from a Chlorella vulgaris biomass on expression of interferon-γ and interleukin-2 in chicken peripheral blood mononuclear cells.

Optimization of the culture medium and characterization of antioxidant compounds of a marine isolated microalga as a promising source in aquaculture feed.

Phytochemical constituents and biological activities of Salvia macrosiphon Boiss.

. Effect of surfactants on photocatalytic toxicity of TiO2-based nanoparticles toward Vibrio fischeri marine bacteria.

. review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy.

A review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy

Alteration in inflammatory mediators in 7 seriously eye-injured war veterans, long-term after sulfur mustard exposure

Alteration in inflammatory mediators in seriously eye-injured war veterans, long-term after sulfur mustard exposure.

Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease.

Effect of surfactants on photocatalytic toxicity of TiO2-based nanoparticles toward Vibrio fischeri marine bacteria

Production of Functional Fermented Milk by Isolated Lactobacill from Traditional Iranian Dairy Products

review on progression of epidermal growth factor receptor (EGFR) inhibitors as an efficient approach in cancer targeted therapy.

Structural analysis of ACE-inhibitory peptide (VL-9) derived from Kluyveromyces marxianus protein hydrolysate.

. In vitro and in silico studies of novel synthetic ACE-inhibitory peptides derived from Saccharomyces cerevisiae protein hydrolysate

. In vitro and in silico studies of novel synthetic ACE-inhibitory peptides derived from Saccharomyces cerevisiae protein hydrolysate.

A comparative study on the shape-dependent biological activity of nanostructured zinc oxide.

Anti-algal activity of Fe2O3-TiO2 photocatalyst on Chlorella vulgaris species under visible light irradiation

Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives

Anti-cancer, anti-oxidant and molecular docking studies of thiosemicarbazone indole-based derivatives.

Antioxidant activity and protective effects of Saccharomyces cerevisiae peptide fractions against H2O2-induced oxidative stress in Caco-2 cells

Antioxidant activity and protective effects of Saccharomyces cerevisiae peptide fractions against H2O2-induced oxidative stress in Caco-2 cells.

Apoptosis Induction of Armeniacae Semen Extractin Human Acute Leukemia (NALM-6 and KG-1) Cells

Apoptosis Induction of Armeniacae Semen Extractin Human Acute Leukemia (NALM-6 and KG-1) Cells.

Cytotoxic and antioxidant activities of Crocus pallasii subsp. haussknechtii corms extracts compared with Crocus sativus

Cytotoxic and antioxidant activities of Crocus pallasii subsp. haussknechtii corms extracts compared with Crocus sativus.

Cytotoxic Evaluation of Daphne pontica L. Aerial Part Extracts on Three Cancerous Cell Lines by MTT Assay

Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study

Design, synthesis and in vitro cytotoxicity of new 1,2,3-triazol- and nitrostyrene hybrids as potent anticancer agents.

Design, Synthesis, and Cytotoxicity of Novel Coumarin-1,2,3- 9 triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents

Design, Synthesis, and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents.

In vitro and in silico studies of novel synthetic ACE-inhibitory peptides derived from Saccharomyces cerevisiae protein hydrolysate

In vitro and in silico studies of novel synthetic ACE-inhibitory peptides derived from Saccharomyces cerevisiae protein hydrolysate.

Oliveria decumbens, a Bioactive Essential Oil: Chemical Composition and Biological Activities.

Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies

Preparation of some novel imidazopyridine derivatives of indole as anticancer agents: one-pot multicomponent synthesis, biological evaluation and docking studies.

Synthesis and Anticancer Activity of N-(di/trimethoxyaryl)-5-arylisoxazole-3-carboxamide, Polycyclic Aromatic Compounds.

Synthesis, in vitro and cellular antioxidant activity evaluation of novel peptides derived from Saccharomyces cerevisiae protein hydrolysate: structure-function relationship : Antioxidant activity and synthetic peptides. Amino Acids.

Synthesis, in vitro and cellular antioxidant activity evaluation of novel peptides derived from Saccharomyces cerevisiae protein hydrolysate: structure–function relationship

Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.

The comparison of the apoptosis effects of titanium dioxide nanoparticles into MDA-MB-231 cell line in microgravity and gravity conditions.

مروری بر گرفتگی زیستی در غشاهای اسمز معکوس جهت نمک زدایی آب دریا

Chemodiversity of Nepeta menthoides Boiss. & Bohse. essential oil from Iran and antimicrobial, acetylcholinesterase inhibitory and cytotoxic properties of 1,8-cineole chemotype

In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA.

. Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3',7-dichloroflavanone and 3',6-dichloroflavanone, on human breast and prostate cancer cell

. Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives

Bio-guided isolation of Centaurea bruguierana subsp. belangerana cytotoxic components.

Caspasedependent apoptosis induced by two synthetic halogenated flavanones, 3',7- dichloroflavanone and 3',6-dichloroflavanone, on human breast and prostate cancer cell

Chemodiversity of Nepeta menthoides Boiss. & Bohse. essential oil from Iran and antimicrobial, acetylcholinesterase inhibitory and cytotoxic properties of 1,8-cineole chemotype.

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic, and docking study.

Design, synthesis, docking study, α-glucosidase inhibition, and cytotoxic activities of acridine linked to thioacetamides as novel agents in treatment of type 2 diabetes

Design, synthesis, docking study, α-glucosidase inhibition, and cytotoxic activities of acridine linked to thioacetamides as novel agents in treatment of type 2 diabetes.

Design, synthesis, in vitro cytotoxic activity evaluation, and study of apoptosis inducing effect of new styrylimidazo[1,2- a]pyridines as potent anti-breast cancer agents.

Design, synthesis, in vitro cytotoxic activity evaluation, and study of apoptosis inducing effect of new styrylimidazo[1,2-a]pyridines as potent anti-breast cancer agents.

Evaluation of biochemical differences and immunostimulatory properties of lps and lipid a extracted from brucella strains.

Identification and anticancer activity in 2D and 3D cell culture evaluation of an Iranian isolated marine microalgae Picochlorum sp. RCC486.

In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA.

Novel quinazolin-4(3H)-one linked to 10 1,2,3-triazoles: Synthesis and anticancer activity.

Novel quinazolin-4(3H)-one linked to 1,2,3-triazoles: Synthesis and anticancer activity.

Photocatalytic inactivation of Vibrio fischeri using Fe2 O3 -TiO2 - based nanoparticles

Photocatalytic inactivation of Vibrio fischeri using Fe2 O3 -TiO2 -based nanoparticles.

Photocatalytic inactivation of Vibrio fischeri using Fe2O3-TiO2-based nanoparticles.

Phytochemical constituents and biological activities of Salvia suffruticosa

Statistical optimization of medium with response surface methodology for biomass production of a local Iranian microalgae Picochlorum sp. RCC486

Statistical optimization of medium with response surface methodology for biomass production of a local Iranian microalgae Picochlorum sp. RCC486.

Synthesis and biological evaluation of 2-phenyl benzothiazole derivatives as cytotoxic agents

Synthesis and biological evaluation of 4-amino-5- cinnamoylthiazoles as chalcone-like anticancer agents

Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents.

Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety

Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety.

Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives

The effect of extraction method on the major constituents and biological effects of Trachyspermum ammi L. fruits

تأثیر بتانین چغندر قرمز بر سندرم تخمدان پلي كیستیك القاء شده در رت

Synthesis of novel chromenones linked to 1, 2, 3-triazole ring system: Investigation of biological activities against Alzheimer’s disease

. Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines.

Anticancer effects of synthetic hexahydrobenzo [g]chromen-4-one derivatives on human breast cancer cell lines

Biological activities of the essential oil and total extract of Salvia macrosiphon Boiss.

Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8- amines.

In vitro and in vivo evaluation of Paclitaxel-Lapatinib loaded F127 Pluronic micelles

Synthesis 12 and biological evaluation of novel imidazopyrimidin-3-amines as anticancer agents.

Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents

Synthesis and biological evaluation of novel imidazopyrimidin-3-amines as anticancer agents

Synthesis of novel chromenones linked to 1, 2, 3-triazole ring system: Investigation of biological activities against Alzheimer’s disease.

1,2,3-Triazole-Isoxazole Based Acetylcholinesterase Inhibitors: Synthesis, Biological Evaluation and Docking Study.

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

In vitro cytotoxic effect of urtica dioica extracts on acute myelogenous leukemia cell line (KG-1)

Novel Tacrine-Based Pyrano[3’,4’:5,6]pyrano[2,3-b]quinolinones: Synthesis and Cholinesterase Inhibitory Activity

Novel Tacrine-Based Pyrano[3’,4’:5,6]pyrano[2,3-b]quinolinones: Synthesis and Cholinesterase Inhibitory Activity.

Synthesis and cytotoxicity of novel chromenone derivatives bearing 4-nitrophenoxy phenyl acryloyl moiety

The development of biomarkers to reduce attrition rate in drug discovery focused on oncology and central nervous system

The efficacy of iranian traditional and folk medicinal plants for some gastroduodenal disorders

Treatment of Helicobacter pylori infection: current and future insights.

A Systematic Review of Drugs in Late-Stage Development for the Treatment of Multiple Sclerosis: A Focus on Oral Synthetic Drugs.

Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids

Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles

Discovery approaches for novel dyslipidemia drugs.

Novel N-2-(Furyl)-2-(chlorobenzyloxyimino) ethyl Piperazinyl Quinolones: Synthesis, Cytotoxic Evaluation and Structure-activity Relationship

Synthesis and anticancer activity of N-substituted 2- 14 arylquinazolinones bearing trans-stilbene scaffold

Synthesis and cytotoxic activity of novel poly-substituted imidazo[2,1-[Formula: see text]][1,2,4]triazin-6-amines

Synthesis and in vitro cytotoxic activity of N-[2-(thienyl)-2- (chlorobenzyloxyimino)]ethyl enoxacin derivatives

Synthesis and In vitro cytotoxic activity of novel Triazole-Isoxazole derivatives.

Synthesis, antileishmanial activity and QSAR study of (1,3,4-thiadiazol-2-ylthio) acetamides derived from 5-nitrofuran

اثر سمیت سلولی الیگوی آنتی سنس RNA ژن کلاسترین با داروی دستاکسل در دو دودمان سلولی سرطان پروستات

Synthesis, crystal structure, and cytotoxic activity of novel cyclic systems in [1,2,4]thiadiazolo[2,3- a]pyridine benzamide derivatives and their copper(II) complexes.

Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines.

Design, synthesis, docking study and cytotoxic activity evaluation of some novel letrozole analogs.

Medicinal plants in the treatment of Helicobacter pylori infections.

Synthesis and anti-cancer activity evaluation of new dimethoxylated chalcone and flavanone analogs

Synthesis and anti-cancer activity evaluation of new dimethoxylated chalcone and flavanone analogs.

Synthesis and cytotoxic evaluation of some new [1,3]dioxolo[4,5-g]chromen-8-one derivatives

Synthesis and evaluation of antiproliferative activity of substituted N-(9-oxo-< i> 9H</i>-xanthen-4- yl) benzenesulfonamides.

Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents.

اثر ریزپوشانى بر قابلیت زنده مانی لاکتوباسیلوس کازئى در شرایط شبیھ سازى شده معده و روده و تیمار حرارتى

2-Amino-4- (nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents.

New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)- thiazole thiones as combretastatin analogs.

Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7- methoxychroman-4-one derivatives.

Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone.

Synthesis and in vitro Cytotoxic Activity of Novel Chalcone-like Agents.

Synthesis, Cytotoxicity Assessment, and Molecular Docking of 4-Substituted-2-p-tolylthiazole Derivatives as Probable c-Src and erb Tyrosine Kinase Inhibitors.

The importance of synthetic drugs for type two diabetes drug discovery

2-Amino-3-cyano-4-(5-arylisoxazol-3- yl)-4H-chromenes: Synthesis and In vitro Cytotoxic Activity

Asymmetrical 2,6 bis(benzylidene)cyclohexanones: Synthesis, cytotoxic activity and SAR study

Cytotoxic activity evaluation and QSAR study of chromene-based chalcones.

Halogenated flavanones as potential apoptosis-inducing agents: synthesis and biological activity evaluation

Synthesis, molecular docking and cytotoxicity evaluation of 2-(4-substituted-benzyl) isoindoline-1, 3-dione deriva-tives as anticancer agents.

., In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori

Coumarin-based bioactive compounds: facile synthesis and biological evaluation of coumarin-fused 1,4-thiazepines

Coumarin-based bioactive compounds: facile synthesis and biological evaluation of coumarin-fused 1,4-thiazepines.

In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori

Synthesis and in vitro cytotoxic activity of N-2-(2-furyl)-2- (chlorobenzyloxyimino) ethyl ciprofloxacin derivatives

Synthesis and in vitro cytotoxic activity of N-2-(2-furyl)-2-(chlorobenzyloxyimino) ethyl ciprofloxacin derivatives.

Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics

Effectiveness of fluconazole for suppressive maintenance therapy in patients with rvvc: a randomized placebo-controlled study.

Synthesis and cytotoxic activity of novel 9- [hydroxy(substitutedphenyl) methyl]-2,2-dimethyl-2,3,8,9-tetrahydro-4H,10H- 18 pyrano[2,3-f]chromene-4,10-diones

Synthesis and in-vitro cytotoxicity of poly-functionalized 4-(2-Arylthiazol-4-yl)-4Hchromenes

Synthesis and structureactivity relationship study of 2-substituted- 5-(5- nitro-2-thienyl)-1,3,4-thiadiazoles as anti-helicobacter pylori agents

Evaluation of Anti-Helicobacter pylori Activity of Twelve Medicinal Plants from Iran

In vitro cytotoxicity and apoptotic inducing activity of the synthesized 4-aryl-4H-chromenes derivatives against human cancer cell lines

Synthesis and in vitro antibacterial activity of N-[5-(5-nitroaryl)-1,3,4-thiadiazol-2-yl]-piperazinyl quinolones

Enhancement of the antibacterial activity of ciprofloxacin against staphylococcus aureus by 3-alkyl esters and 19 3-aryl esters of hexahydroquinoline derivatives.

Evaluation of anti-helicobacter pylori activity of methanol extracts of some species of stachys and melia

Structure- activity relationship study of a series of n-substituted piperazinylfluoroquinolones as anti-Helicobacter pylori agents

Relation of microalbuminuria with hypertension and diabetes in patients with cardiovascular disease

Relationship between microalbuminuria and extension of coronary atherosclerotic lesions

Production of polyclonal antibody against rat immunoglobulins in goats.

High sensitive-CRP (HS-CRP): a predictive risk factor and new marker of cardiovascular disease.

ثبت اختراع

ثبت اختراع:

سنتز ترکیبات هتروسیکلیکی داروی ضد الزایمر ریواستیگمین و ارزیابی قابلیت مهار انزیم های استیل و بوتیریل کولین استراز

دروس

دروس:

New subjects in cellular and molecular biology (Ph.D students)
-Cellular and molecular processes in eukaryotes (Ph.D students)
-Metabolic Engineering (Ph.D students)
-Cellular and Molecular Biology of Cancer (Ph.D students)
-Medicinal Chemistry for Master students (Ph.D students)
-Advanced Research Methodology (Ph.D students)
-Macromolecules Structure and Function (Master students)
-Tissue & cell culture (Bsc students)
-Animal biotechnology (Bsc students)
-Biochemistery for (Bsc students)
-Biochemistry of Hormone (Bsc students)
-Biochemistry of Carbohydrates and Lipides (Bsc students)
-فرآوری زیست مواد در میکروارگانیسم ها

کارگاه ها و دوره های آموزشی

کارگاه ها و دوره های آموزشی:

مدرس کارگاه های کشت سلولی در ادوار زمانی و دانشگاه های مختلف
مدرس کارگاه های روش تحقیق و مقاله نویسی
مدرس کارگاه های پرهیز از پلاجیاریزم

تجربه های تحقیقاتی

تجربه های تحقیقاتی:

Previous Projects:
Involving in 65 project as co-investigator
Principal investigator in (Some projects are included):

Evaluation of complexes of 2-hydroxyacetophenone semicarbazones as novel series of superoxide dismutase mimetics
Synthesis and evaluation of in vitro anticancer activity of quinazoline derivatives.
In-vitro anti-cancer and apoptosis inducing activity of some synthetic compounds on several human cancer cell lines
Design, synthesis and evaluation of anti-cancer activity of novel benzo[7,8]chromeno [2,3-d]pyrimidin as tyrosin kinase inhibitors.
Evaluation of anticancer and antioxidant activities of marine microalgae from Iran

Current Projects:
Involving in 15 project as co-investigator
Principal investigator in:

In vitro anticancer and antioxidant activity of essential oil and extract of from ipomoea leaves against human cancer cell lines and their molecular mechanism.
Anticancer and antioxidant activities of green microalgae of Persian Gulf on breast cancer cell lines.
Design and Synthesis of Mesoporous Nano Silica Vehicle for siRNA delivery against EGFR1 in a Human Breast Cancer cell line.
Extraction, Characterization and Biological Activity Evaluation of Exo-polysaccharides From Isolated Strains of Persian Gulf Chlorophyta.
Neuroprotective compounds from marine origine.

عضویت در مجامع

عضویت در مجامع:

عضو هیئت تحریریه نشریه علمی، پژوهشی Biologia
عضو کمیته تخصصی زیست فناوری و علوم پایه پزشکی سی و سومین جشنواره بین المللی خوارزمی
ریاست کمیته تخصصی پزشکی سی و سومین جشنواره بین المللی خوارزمی
ریاست کمیته تخصصی جشنواره خوارزمی جوان
عضویت در کمیته تخصصی طرح برگزیده موفق در تولید ملی سی و ششمین جشنواره بین المللی خوارزمی
عضویت در کمیسیون تخصصی پژوهشکده زیست فناوری دوره دهم هیات ممیزه
عضویت در هیات ممیزه سازمان
عضویت در کمیته Technical Advisory Committee COMSATS

جوایز

جوایز:

دانشجوی استعداد درخشان در مقاطع تحصیلی
پژوهشگر برتر سازمان در سال 1394
پژوهشگر برتر پژوهشکده زیست فناوری در سال 1401
پژوهشگر برتر سازمان در سال 1402
تقدیر نامه از ریاست سازمان و معاونت وزیز بابت برگزاری 24 امین کنگره بین المللی میکروب شناسی به عنوان دبیر اجرایی

مهارت ها و تجربه های تخصصی

مهارت ها و تجربه های تخصصی:

PhD thesis title: Evaluation of synergistic cytotoxic activity of flavanon derivatives with Toll like receptor 3 agonist on three cancer cell line.
Msc thesis title: Relationship between microalbuminuria and extension of coronary atherosclerotic lesions.
Other research area: Enzyme assay , Cell culture, 3D-Cell culture, SDS-PAGE, Western blotting, Electrophoresis, Enzyme assay, Nanoparticles, Synthesis in organic chemistry lab, Chromatography, SRID, Auto analyzer,...
Experience in Cytogenetics for two (2) years. (Including: karyotype and chromosome analysis by method G-banding.)

تجربیات حرفه ای

تجربیات حرفه ای:

داوری مجله Microbiology, Metabolites and Biotechnology
داوری مجله Journal of Particle Science and Technology
داوری مقاله در مجله DARU Journal of Pharmaceutical Sciences (ISI)
داوری مقاله در مجله Journal of Molecular Structure (ISI)
داوری مقاله در مجله Food Bioscience (ISI)
داوری مقاله در مجله Journal of Chemotherapy (ISI)
داوری مقاله در مجله Molecules (ISI)
داوری مقاله در مجله International Journal of Food Properties (ISI)
داوری طرح در 25 امین جشنواره جوان خوارزمی (زيرگروه تخصصي زيست فناوري صنعت و محيط زيست)
داوری طرح در 25 امین جشنواره جوان خوارزمی (زیر گروه تخصصی علوم پایه)
داوری طرح سی و ششمین جشنواره بین المللی خوارزمی
داوری طرح در گروه تخصصی طرح برگزیده موفق در تولید ملی سی و ششمین جشنواره بین المللی خوارزمی
داوری طرح ارتباط با صنعت
سرداوری طرح های اختراعی
ارزيابي توانمندي فناورانه اظهار شده
داوری طرح صندوق حمایت از پژوهشگران (بنیاد علم ایران)
برپایی نمایشگاه جانبی در 24امین کنگره بین المللی میکروب شناسی

سوابق اجرایی

سوابق اجرایی:

مدیر کل آزمایشگاه مرجع
معاون پژوهشکده بیوتکنولوژی
ریاست پژوهشکده بیوتکنولوژی
دبیر اجرایی 24 امین کنگره بین المللی میکروب شناسی ایران
عضو هیات تحریریه نشریه علمی پژوهشی Biologia
عضو هیات تحریریه نشریه علمی پژوهشی Biotechnological Journal of Environmental Microorganisms
مسئولیت راه اندازی و مدیریت ازمایشکاه تخصصی کشت سلولی
رئیس گروه تخصصی زیست فناوری و علوم پایه پزشکی سی و ششمین جشنواره بین المللی خوارزمی
رئيس گروه تخصصي زيست فناوري و علوم پايه پزشكي بيست و پنجمين جشنواره جوان خوارزمي

پایان نامه ها

پایان نامه ها:

اثرات آنتي اكسيداني و نوروپروتكتيو عصاره ميكروالگ ها از شاخه كلروفيتا جدا شده از خليج فارس روي رده سلولي pc12، سعيد نيازي، دانشگاه تهران
عصاره گيري و بررسي اثرات سيتوتوكسيك و القا آپوپتوز عصاره هاي نختلف آلي ميكروالگ هاي سبز جدا شده از خليج فارس و شناسايي موثرترين ميكروالگ ها، علي لشگري، دانشگاه تهران
تاثیر اوژنول بر پارامتر های بیوشیمیایی و هیستولوژیکی موش های نر نژاد NMRI با رژیم پرچرب، یاسمن الماسی زاده یاقوتی، دانشگاه ازاد علوم تحقیقات
مقایسه میزان تاثیر نانوذرات TiO2 برمرگ سلولی سلولهای ادنوکارسینومای سینه MDA-MB-231 در شرایط میکروگراویته و گرانش طبیعی، محدثه ربیع زاده، دانشگاه ازاد علوم تحقیقات
بهبود اثرات ضدسرطانی داروی دوکسوروبیسین انتقال یافته توسط نانو ذرات مزو ساختار سیلیکای متخلخل (MSN- COOH) اصلاح شده با گروه عاملی اسیدی، مهین نوری، دانشگاه علوم تحقیقات
سنتز و بررسي اثرات ضد سرطان سينه مشتقات امينوتيازول بر روي سه رده سلول سرطان سينه، عديله ايتي، دانشگاه علوم پزشكي تهران
بررسي اثر عصاره گياهي دانه هاي بادام تلخو زردالو بر رده هاي سلولي لنفوئيدي حاد و لوسمي ميلوئيدي حاد، شيوا مصدق منشاذي، دانشگاه علوم پزشكي تهران
بررسی اثر ضد سرطانی و القاء آپوپتوز عصاره برگ و سرشاخه های گیاه Ailanthus altissima بر روی سه رده سلول سرطان سینه، رایموند آساتوری، علوم تحقیقات
ارزيابي فعاليت زيستي (ضد سرطاني، ضد ميكروبي و آنتي اكسيداني) چند سويه سيانوباكتري بومي ايران، صدیقه مومن نژاد، دانشگاه علوم تحقیقات
روش تلفیقی اکسیداسیون پیشرفته و ماده فعال سطحی در پیش تصفیه واحد اسمز معکوس براي پیشگیري از گرفتگی زیستی، حامد بنی عامریان، سازمان پژوهش های علمی و صنعتی ایران
تولید صنعتی داروی ریواستیگمین و سنتز مشتفات S- تبیوکاربامات آزولی آن، اکرم فلاح، سازمان پژوهش های علمی و صنعتی ایران
بررسی فیتوشیمیائی اسانس گل اروانهی اورامانی) و اثر آن بر تکثیرHymenocrater longiflorus Benth سلولهای سرطان سینه، پهشیو محمدی، دانشگاه کردستان
ارزیابی اثر مهارکنندگی آنزیم تیروزیناز توسط مشتقات تیوسمی کاربازید به همراه بررسی روش مهار آنزیم، علی تشرعی، دانشگاه علوم پزشکی تهران
ارزیابی اثرات ضدسرطانی دوکسوروبیسین و پردنیزولون انتقال داده شده با استفاده از نانوکامپوزیت سیلیکا مزوحفره/گرافن اکساید در سلول های سرطان سینه و ریه، یاسمین چروم، دانشگاه محقق اردبیلی

دانشجویان

دانشجویان دکترا

دانشجویان دکترا:

خانم. زهرا موسویان کچویی

دیگر دانشجویان

دیگر دانشجویان:

جواد پرنیان- ملیحه بختیاری زاده- مریم صفری-

رزومه

Dr SAFAVI (CV)-2024.pdf